We were unable to identify any randomized controlled trials that have utilized intramuscular B52 for aggression. 1–11 Four articles were excluded because they analyzed medications not available in the United States (zuclupenthixol, levomepromazine, and flunitrazepam), resulting in 7 final articles for this review. A screening of the titles and abstracts with inclusion/exclusion criteria resulted in a total of 11 articles. The initial search resulted in 1,481 articles. PubMed was searched with the following MeSH terms: aggression AND randomized controlled trial. We excluded all studies that were not randomized controlled trials. We excluded children and adults with a primary neurologic disorder such as dementia. Only randomized controlled trials were included. Inclusion criteria were adults with or without psychiatric conditions who were treated with an intramuscular agent for aggression.
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